L-carnitine: Izinzuzo Zayo, Imithombo kanye Nemiphumela engemihle

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I-L-carnitine iyi-amino acid, ekhiqizwa ngokwemvelo emzimbeni. Isakhi se-amino acid siyisengezo esivame ukusetshenziswa. Isakhamzimba sidlala indima enkulu ekukhiqizeni amandla emzimbeni wakho. Ngokuhambisa ama-fatty acids emzimbeni wakho kwi-mitochondria, nawo, asiza ukushisa amanoni futhi uwaguqule abe ngamandla.

I-L-carnitine ikhiqizwa emzimbeni wakho, ekhiqizwa kusuka kuma-amino acid lysine ne-methionine. Ukuze umzimba wakho ukhiqize inani elidingekayo le-L-carnitine, kufanele ube novithamini C omningi ngaphandle kwalokhu, i-L-carnitine ingatholwa futhi ngamanani amancane ngokudla ukudla okufana nenyama, ubisi, inhlanzi njll. ibuye itholakale ngesimo sezithasiselo ^{[1] [okubili]} .

I-amino acid iyindlela ejwayelekile esebenzayo ye-carnitine (igama elijwayelekile lenhlanganisela ye-quaternary ammonium ebandakanyeka ekuguqulweni kwezilwane ezincelisayo, ezitshalweni nakwamanye amabhaktheriya), etholakala futhi ngesimo se-D-carnitine, i-Acetyl-L-carnitine, I-Propionyl-L-carnitine, ne-L-carnitine L-tartrate ^[3] .

Izinzuzo Zezempilo ze-L-carnitine

1. Ukwehla kwesisindo sengculazi

U-L-carnitine udume ezikhathini zamuva ngekhono lakhe elihlongozwayo lokusiza ukunciphisa umzimba. Isengezo se-amino acid sisebenza ngokuhambisa ama-fatty acid kumaseli akho, azoshiswa abe amandla. Yize kube nokuphikisana emandleni ekhompiyutha yokukhuthaza ukwehla kwesisindo, isifundo esenziwe kubantu abakhuluphele kakhulu sisekele isimangalo sokuthi i-L-carnitine iyasiza ekunciphiseni isisindo ^[4] .

2. Ithuthukisa ukusebenza kobuchopho

Ezinye izifundo zikhombe ukuthi i-L-carnitine ingasiza ekuthuthukiseni ukusebenza kwengqondo yakho. Lokho wukuthi, kungasiza ekuvimbeleni ukuncipha kwengqondo okuhlobene nobudala, kusize ekuthuthukiseni ikhono lomuntu lokufunda, futhi kusize ukubuyisela emuva ukwehla kokusebenza kobuchopho ukuvimbela ukuqala kwe-Alzheimer's nezinye izifo zobuchopho ^[5] .

3. Iphatha impilo yenhliziyo

I-L-carnitine ixhunyaniswe nokunciphisa ukucindezelwa kwegazi kanye nenqubo yokuvuvukala ehambisana nesifo senhliziyo. Kuphinde kwaqinisekiswa ukuthi kunamandla okuthuthukisa isimo sabantu abanenkinga enkulu yenhliziyo, njengesifo senhliziyo nokuhluleka kwenhliziyo okungamahlalakhona ^[6] .

4. Kuqinisa ukusebenza

Izifundo ezahlukahlukene ziveze izinzuzo, yize zincane, i-L-carnitine inokwenza ngcono ukusebenza kwezemidlalo komuntu. Ngenxa yalesi sakhiwo, i-L-carnitine igama elijwayelekile emkhakheni wezemidlalo. Kungasiza ekuthuthukiseni ukuvuselelwa kwakho kokuzivocavoca umzimba, kwandise ukunikezwa kwe-oksijini emisipheni yakho, kuthuthukise ukuqina kwakho, kunciphise ubuhlungu besisu futhi kwandise ukukhiqizwa kwamaseli abomvu ^[3] .

5. Ilawula isifo sikashukela

I-L-carnitine ingakusiza ukuphatha nokunciphisa izimpawu zesifo sikashukela, ikakhulukazi uhlobo lwesifo sikashukela sohlobo 2. Kuyasiza nasekulawuleni izinto ezinobungozi zalesi simo, njengoba i-amino acid ingasiza ekwehliseni amazinga kashukela egazini ^[6] .

Kuthiwa futhi inenzuzo yokunikeza ukukhululeka ebuhlungwini besifuba, isifo sezinso, i-hyperthyroidism, ukungazali kwabesilisa, izinduna, ukulahleka kwezinwele, i-autism, ukushaya kwenhliziyo okungajwayelekile, imithambo yegazi evimbekile, ukukhathala, isisindo sokuzalwa esiphansi nokunye okuhlukahlukene. Kodwa-ke, kukhona ukuntuleka kwezifundo ekusetshenzisweni okunwetshiwe nokusebenza kwe-L-carnitine ezimweni ezahlukahlukene ^[7] .

Imiphumela emibi ye-L-carnitine

I-L-carnitine supplements noma imijovo, yize iphephile ekusetshenzisweni komuntu, ingadala imiphumela emibi kubantu abathile. Eminye yemiphumela emibi ejwayelekile ye-amino acid ishiwo ngezansi ^[8] .

• Isicanucanu
• Ukuhlanza
• Ubuhlungu besisu
• Isilungulela
• Uhudo
• Ukuquleka
• Iphunga elinenhlanzi ngomchamo, umoya nokujuluka

Ngaphandle kwalokho, abesifazane abakhulelwe nabancelisayo kufanele bakugweme ukudla i-L-carnitine ^[9] . Ukweqisa kwe-L-carnitine kungadala ukwehluleka kwezinso, futhi kubhebhethekise nezimpawu ze-hypothyroidism. Futhi, gwema ukusebenzisa i-L-carnitine yokulawula ukuquleka, uma usuvele waquleka ngaphambili.

Isilinganiso se-L-carnitine

Qaphela: Kufanele ubonane nodokotela ngaphambi kokufaka izengezo ze-L-carnitine noma imijovo emikhubeni yakho.

Umthamo oshiwo lapha ngowabantu abadala ^[10] .

Ukushoda kwe-L-carnitine: 990 mg, kabili kuya kathathu nsuku zonke (amaphilisi noma isisombululo somlomo).

Ubuhlungu besifuba: 900 mg kuya ku-2 g ngemithamo ehlukanisiwe engu-1 kuye kwezi-2 nsuku zonke amaviki ama-2 kuye ezinyangeni eziyisithupha.

Umthamo ojwayelekile we-L-carnitine ungama-500-2,000 mg ngosuku.

Encwadini Yokugcina ....

Okwe-vegans, ukukhiqiza kanye nokuthola i-L-carnitine kungenzeka kungenzeki ngenxa yokuntuleka kwenyama nenhlanzi. Okufanayo kuya kubantu abaphethwe yizinkinga ezithile zofuzo. Kodwa-ke, umuntu angathola inani elidingekayo le-L-carnitine ngokusebenzisa izithasiselo ze-L-carnitine.

1. [1]Inkambu, R., Riede, L., Lugo, J., & Bellamine, A. (2018). l-Carnitine supplementation ekululameni ngemuva kokuzivocavoca. Izondli, 10 (3), 349.
2. [okubili]UKoeth, R. A., Lam-Galvez, B. R., Kirsop, J., Wang, Z., Levison, B. S., Gu, X., ... & Culley, M.K (2018). l-I-Carnitine ekudleni oku-omnivorous yenza indlela ye-atherogenic gut microbial path ebantwini. Ijenali Yokuphenywa Kwemitholampilo, i-129 (1), 373-387.
3. [3]UNovakova, K., Kummer, O., Bouitbir, J., Stoffel, S. D., Hoerler-Koerner, U., Bodmer, M., ... & Krähenbühl, S. (2016). Umphumela we-l-carnitine supplementation echibini le-carnitine lomzimba, amandla emisipha yamandla emisipha nokusebenza komzimba kwabesilisa abadla imifino kuphela. Ijenali yaseYurophu yokudla okunempilo, 55 (1), 207-217.
4. [4]U-Lee, B. J., uLin, J. S., uLin, uY.C, noLin, uPT (2015). Imiphumela ye-antiinfigueatory ye-L-carnitine supplementation (1000 mg / d) ezigulini zezifo zomthambo we-coronary Nutrition, 31 (3), 475-479.
5. [5]UChan, Y. L., Saad, S., Al-Odat, I., Oliver, B. G., Pollock, C., Jones, N. M., & Chen, H. (2017). Isengezo se-Maternal L-carnitine sithuthukisa impilo yobuchopho enzalweni evela emsini kagwayi oveze omama.Izikhulu ze-neuroscience yamangqamuzana, 10, 33.
6. [6]UFukami, K., Yamagishi, S. I., Sakai, K., Kaida, Y., Yokoro, M., Ueda, S., ... & Okuda, S. (2015). I-Oral L-carnitine supplementation inyusa i-trimethylamine-N-oxide kepha inciphisa omaka bokulimala emithanjeni ezigulini ze-hemodialysis. Ijenali ye-pharmacology yenhliziyo, 65 (3), 289-295.
7. [7]da Silva, G. S., de Souza, C. W., da Silva, L., Maciel, G., Huguenin, A. B., de Carvalho, M., ... & Colafranceschi, A. (2017). Umphumela we-L-Carnitine Supplementation on Reverse Remodeling in Patients with Ischemic Heart Disease Undergoing Coronary Artery Bypass Grafting: A Randomized, Placebo-Control Trial.Annals of nutrition & metabolism, 70 (2), 106.
8. [8]U-Lee, B. J., uLin, J. S., uLin, uY.C, noLin, uPT (2016). Imiphumela ye-L-carnitine supplementation kumaphrofayili we-lipid ezigulini ezine-coronary artery disease.Lipids kwezempilo kanye nezifo, 15 (1), 107.
9. [9]UPala, R., Genc, ​​E., Tuzcu, M., Orhan, C., Sahin, N., Er, B., ... & Sahin, K. (2018). Ukwengezwa kwe-L-Carnitine kwandisa ukubonakaliswa kwe-PPAR-γ kanye nabathuthi be-glucose emisipha yamathambo yamagundane asebenza ngokungapheli futhi asebenza kahle. Ibhayoloji yeselula neyamangqamuzana (Noisy-le-Grand, France), 64 (1), 1-6.
10. [10]Imbe, A., Tanimoto, K., Inaba, Y., Sakai, S., Shishikura, K., Imbe, H., ... & Hanafusa, T. (2018). Imiphumela ye-L-carnitine supplementation kwikhwalithi yempilo ezigulini ezinesifo sikashukela ezinamajaqamba emisipha. Iphephabhuku i-Endocrine, i-EJ17-0431.

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