Ukuhlolwa Kwegazi Kungasiza Ukuthola Umdlavuza Webele, Kusho Ukufunda Kwamuva

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Umdlavuza webele uhlobo oluvame kakhulu lomdlavuza ongesona isikhumba. Kuthiwa ingenye yezinhlobo zomdlavuza ezivame kakhulu ezithinte abantu, ikakhulukazi kule minyaka eyishumi edlule. ENdiya kuphela, kubikwa izehlakalo ezingaphezu kwesigidi esisodwa somdlavuza webele minyaka yonke.

Njengombiko wakamuva kakhulu, kulindeleke ukuthi kube nokuhlonza okusha okungaba ngu-252, 710 kwabesifazane, kanti abesifazane ababalelwa ku-40,610 kungenzeka babulawe yilesi sifo. Umdlavuza webele akuyona eyabesifazane kuphela, ngoba ingathinta nabesilisa. Abantu abangaphezu kuka-9 500 bafuna ukunakekelwa komdlavuza webele unyaka nonyaka futhi abantu ababalelwa ku-1,500 bayahlinzwa unyaka ngamunye ^[1] .

Umdlavuza webele uvela lapho amangqamuzana amabele eqala ukukhula ngokungajwayelekile, bese ephindaphindeka ngokushesha kunamaseli aphilile bese eqhubeka nokuphindaphindeka, okuholela ekukhuleni kwesisindo noma isigaxa ^[okubili] . Imvamisa, umdlavuza wamabele utholakele lapho kuvela uphawu noma uphawu futhi kuhlolisiswa ngosizo lwezinqubo nezinqubo ezifana nokuhlolwa kwebele, mammogram , ibele ultrasound njll.

Kodwa-ke, ucwaningo lwakamuva luthi ukuhlolwa kwegazi okusha kungasiza ekutholeni umdlavuza webele kusenesikhathi.

Ukuhlolwa Kwegazi Kungasiza Ukuthola Umdlavuza Webele Eminyakeni engu-5 Ngaphambi Kwezimpawu Ezisobala

Enye yezingozi nezinkinga ezinkulu uma kukhulunywa ngomdlavuza ukutholakala sekwedlule isikhathi. Lapho isimo sesisabalele nakwezinye izindawo, izinga lokusinda liphansi ngokwedlulele ngamathuba okuphindeka ^[3] .

Kodwa-ke, ukuthola kusenesikhathi nokwelashwa okusebenzayo kungasiza ekuthuthukiseni izinga lokufa. Kepha esimweni somdlavuza webele, ukutholwa kwemvelo kusenesikhathi kunqunyelwe njengoba kungakhiphi izimpawu ezisobala ngaso sonke isikhathi, okungaholela ekutholeni sekwedlule isikhathi okungathinta ukusebenza kahle kokwelashwa.

Ocwaningweni lwakamuva olwenziwe ngabaphenyi base-University of Nottingham e-United Kingdom baqinisekisa ukuthi ukuhlolwa kwegazi okuhlola ukutholakala kwama-antibodies athile kungasiza ekutholeni umdlavuza webele kusenesikhathi futhi kalula ^[4] .

Isivivinyo Singathola Ama-Autoantibodies

Abacwaningi baqhubeka bachaza indlela yokuhlolwa kwegazi ngokuchaza ukuthi uma umdlavuza ukhona, umzimba wakho ukhiqiza ama-antigen enza impendulo yomzimba ivikeleke. Lokhu, futhi, kubangela ukuthi amasosha omzimba asabele ezintweni ngokukhipha ama-autoantibodies, azotholwa ngokuhlolwa kwegazi futhi akhombise ukuthi umdlavuza webele ukhona noma cha.

Ekuqaleni, abacwaningi bakhulisa amaphaneli ama-antigen ahlobene nesimila (TAAs) aqondene nomdlavuza webele owasiza ekuqondeni ubukhona bama-autoantigen egazini ahlobene nokuphendula kuma-TAAs aqondene nomdlavuza webele ^[5] .

Omunye wabaphenyi uDaniyah Alfattani uthe, 'Imiphumela yocwaningo lwethu ikhombise ukuthi umdlavuza webele udala ama-autoantibodies ngokumelene nama-antigen athile ahlobene ne-tumor. Sikwazile ukuthola umdlavuza ngokunemba okufanele ngokukhomba lawa ma-autoantibodies egazini ', futhi sagcizelela nesidingo sokwenza nokuqhubeka nokuqinisekisa ukuhlolwa kwegazi ^[6] .

Isifundo Sikhombisa Imiphumela Ethembisayo

Abaphenyi bajabule ngomphumela wocwaningo ngoba imiphumela iyakhuthaza futhi ikhombisa ukuthi kungenzeka ukuthola isignali yomdlavuza webele wokuqala. 'Uma sesikwenze ngcono ukunemba kwesivivinyo, khona-ke kuvula ithuba lokusebenzisa ukuhlolwa kwegazi okulula ukwenza ngcono ukutholwa kwalesi sifo', kusho umcwaningi kahle ^[6] .

Njengoba ucwaningo lunabaphenduli abangaphezu kwama-90, kungacatshangwa ukuthi imiphumela inembe ngokufanele futhi ukuhlolwa kwegazi okusha kungaba lusizo ekusizeni ochwepheshe bezokwelapha nodokotela ukuthola ukutholakala komdlavuza webele kuze kube yiminyaka emi-5 ngaphambi kokuba kuvele izimpawu ezibonakalayo.

Encwadini Yokugcina ...

Njengoba ucwaningo luveza imiphumela emihle, abacwaningi bazimisele ukukhulisa indawo yokufunda ngoba ukuhlolwa kwegazi lokuthola umdlavuza wamabele kusenesikhathi kungabiza kakhulu, futhi kuzosebenza futhi kube yindlela elula yokuhlola uma kuqhathaniswa izinyathelo ezikhona ^[7] . Ukuhlolwa okufanayo kusenzelwa ukuthuthukiswa kwezinye izinhlobo zomdlavuza, kufaka phakathi umdlavuza wamaphaphu, we-pancreatic, we-colorectal, nowesibindi.

1. [1]ULauren, S. & Cassell, M. Ukuhlinzwa kwamabele, Isibhedlela iLenox Hill, eNew York City Alice Police, MD, umqondisi wesifunda saseWestchester, ukuhlinzwa kwamabele, Northwell Health Cancer Institute, Sleepy Hollow, NY NCRI (National Cancer Research Institute, UK), ukukhishwa kwezindaba, Novemba 2, 2019
2. [okubili]Spadafora, C., Sciamanna, I., De Luca, C., Sinibaldi-vallebona, P., Guadagni, F., Schumann, G., & Garaci, E. (2019). U.S. Isicelo se-Patent No. 15 / 564,089.
3. [3]Spadafora, C., Sciamanna, I., De Luca, C., Sinibaldi-Vallebona, P., Guadagni, F., Schumann, G., & Garaci, E. (2019). U.S. Isicelo se-Patent No. 10 / 214,591.
4. [4]UYadav, S., Kashaninejad, N., Masud, M. K., Yamauchi, Y., Nguyen, N. T., & Shiddiky, M. J. (2019). Ama-autoantibodies njenge-biomarker yomdlavuza wokuxilonga nowokubikezela: Amasu wokuthola nezindlela. AmaBiosensors neBioelectronics, 111315.
5. [5]Jiang, X. H., Yao, Z. Y., He, X., Zhang, J. B., Xie, K., Chen, J., ... & Yie, S. M. (2019). Ukubaluleka komtholampilo kwe-plasma anti-TOPO48 autoantibody kanye ne-blood survivin-eveza amaseli omdlavuza ajikeleza ezigulini ezinesigaba sokuqala se-endometrial carcinoma. Izinqolobane zokugcina izifo zabesifazane kanye nezokubelethisa, i-299 (1), 229-237.
6. [6]USeluk, L., Taliansky, A., Yonath, H., Gilburd, B., Amital, H., Shoenfeld, Y., & Kivity, S. (2019). Isikrini esikhulu sokuxilongwa kwe-paraneoplastic neurological autoantibodies namanani wokubikezela. I-Clinical Immunology, 199, 29-36.
7. [7]Khayeka-Wandabwa, C., Ma, X., Cao, X., Nunna, V., Pathak, J. L., Bernhardt, R., ... & Bureik, M. (2019). Ukwakheka kwe-Plasma ulwelwesi lwe-CYP4Z1 ne-CYP19A1 kanye nokutholwa kwama-antiantibodies anti-CYP19A1 ebantwini. I-immunopharmacology yamazwe omhlaba, 73, 64-71.

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