I-Hypertrophic Cardiomyopathy: Izimpawu, Izimbangela, Ukwelashwa Nokuvimbela Buka Isampula Ngezaziso Ezisheshayo VUMELA IZAZISO Ngezaziso Zansuku zonkeVele ungene
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Isifo sikashukela yisifo esibucayi se-metabolic futhi isilinganiso saso sikhula ngokushesha emhlabeni wonke. Ukusetshenziswa kokudla okunama-kilojoule amaningi, indlela yokuphila kanye nokuzuza kwesisindo ngezinye zezinto ezibeka engcupheni isifo sikashukela. Ukushintsha kwendlela yokuphila nokudla kungasiza ekuvikeleni lesi sifo kanye nezinkinga zaso, okwenza umuntu aphile isikhathi eside ngempilo esezingeni. [1]
Izinhlanganisela ezisebenzayo zokulawula amazinga e-glucose nokwenza ngcono i-hyperglycemia zitholakala kokudla okuningi okusebenzayo njengezithelo, amakhambi nemifino. Atholakala kalula emakethe futhi ayabizi.
Ikhukhamba, imifino esetshenziswa kakhulu ingenye yokudla okulawulwa yisifo sikashukela okungokomndeni waseCucurbitaceae. Inokunambitheka okumunyu okuyingqayizivele futhi isetshenziswa emithini yendabuko nasemithini yesintu amakhulu eminyaka. Ikhukhamba lisiza ukunciphisa ukuvuvukala kanye nengcindezi ene-oxidative okuyizimbangela ezinkulu zesifo sikashukela. [okubili]
Kule ndatshana, sizoxoxa ngokuhlangana phakathi kwekhukhamba nesifo sikashukela. Bheka.
Amakhemikhali Asebenzayo Kukhukhamba
Ocwaningweni, izinhlanganisela eziningi ze-bioactive zikhishwe kukhukhamba elibhekele umphumela walo wokulwa nesifo sikashukela. Kubandakanya i-cucurbitacins, i-cucumegastigmanes I ne-II, i-vitexin, i-orientin, i-cucumerin A ne-B, i-apigenin ne-isoscoparin glucoside. [okubili]
Umndeni wakwaCucurbitaceae lapho ikhukhamba ungowawo waziwa ngezakhi zawo zamakhemikhali ezibandakanya ama-saponin, uwoyela oguquguqukayo nongaguquki, ama-flavone, ama-carotenes, ama-tannins, ama-steroids, izinhlaka kanye namaprotheni, okusiza ukuvikela uhla lwezifo, kubandakanya nesifo sikashukela. [3]
Inkomba YeGlycemic Kanye Nemithi Ebalulekile Ekhukhamba
Inkomba ye-glycemic (GI) inombolo eyabelwe izinto zokudla ngokususelwa ekutheni aphakamisa ngokushesha noma kancane kangakanani amazinga eglucose emzimbeni ngemuva kokuwadla. Uma ukudla okuthile kune-GI ephansi, kusho ukukhuphula amazinga e-glucose kancane, ngaleyo ndlela kuncishiswe ubungozi besifo sikashukela nokuphikisana nalokho.
Inkomba ye-glycemic yekhukhamba engu-15, ephansi uma iqhathaniswa nezinye izithelo nemifino efana nethanga namakhabe.
Izakhi zomzimba ezibalulekile kukhukhamba zifaka ifayibha yokudla, amaprotheni, amavithamini (B, C, K), ithusi, i-magnesium, i-potassium, i-phosphorus kanye ne-biotin.
Impahla Elwa Nokuvuvukala Kwekhukhamba
Njengoba sazi, isifo sikashukela siyisifo esingelapheki sokuvuvukala (ukuvuvukala kweziqhingi ze-pancreatic zaseLangerhans), ngakho-ke, ukusetshenziswa kwekhukhamba kungaba yikhambi elisebenzayo lokuvimbela kanye nokuphathwa kwesifo sikashukela ngenxa yempahla yaso elwa nokuvuvukala.
Ngokuya ngocwaningo, amazinga aphezulu eshukela akhuphula amazinga ama-cytokines avuvukalayo nama-fatty acid amahhala, aziwa ngokudala ukumelana ne-insulin emzimbeni.
Ikhukhamba lisiza ukulawula i-hyperglycemia nokuvuvukala. Kuyasiza ukwehlisa amazinga kashukela egazini futhi kuthuthukise ukuzwela kwe-insulin kubantu abanokukhuluphala, kubangele ukuncipha kwamafutha e-visceral ngasikhathi sinye angasiza ekuphathweni kwesisindo futhi ngenxa yalokho, asize ukuphatha isifo sikashukela. [4]
Impahla Elwa ne-Oxidative Yekhukhamba
Ukukhiqizwa kwama-oxygen radicals ngokweqile kanye nezinhlobo ze-carbonyl kungaba nomthelela ekunciphiseni kwezinhlelo zokuvikela i-antioxidant emzimbeni, nakho okungadala ukuqhubekela phambili kwezifo ezingamahlalakhona njengesifo sikashukela.
Ukuba khona kwe-oxygen esebenzayo ne-carbonyl radicals kudala ukulimala kwamaseli nezicubu ngokweba ama-electron awo okwexhuma, okuholela ekufeni kwamaseli.
Ukusetshenziswa njalo kokudla okugcwele ama-antioxidants emvelo kungasiza ekwehliseni ukucindezeleka kwe-oxidative kanye ne-carbonyl stress emzimbeni, ezinye zezizathu eziyinhloko zokuqala isifo sikashukela kanye nezinkinga ezihlobene naso. [5]
Ocwaningweni, imiphumela yokuvikelwa kwamakhemikhali wemvelo ikhukhamba itholwe kumamodeli wokuxineka we-oxidative ne-carbonyl, aziwa ngokudala i-cytotoxicity.
Ikhukhamba livimbela ukwakheka kwezimpawu ze-cytotoxicity kuzo zombili izingcindezi ze-oxidative ne-carbonyl ngenxa yomsebenzi wayo we-antioxidant futhi kusiza ukunciphisa ama-radicals wamahhala emzimbeni. Futhi, umphumela we-anti-hyperglycemic wekhukhamba usiza ekwehliseni amazinga kashukela nokulawula isifo sikashukela. [6]
Umphumela Wekhakhamba Ikhasi Esifo Sikashukela
Esifundweni sokushayela, ukusebenza kwekhasi lekhukhamba kwatholakala kumazinga aphezulu kashukela. Inani eliphephile lekhasi lekhukhamba linikezwe izinsuku eziyi-10 zilandelana, kwalandelwa ukuphathwa kwe-alloxan (isakhi samakhemikhali esibhidliza amangqamuzana akhiqiza i-insulin emanyikwe) ngosuku lwe-11 kanye nele-12 kanye namakhasi wekhukhamba.
Umphumela walokho kwatholakala ukuthi ikhasi lekhukhamba licishe laguqula umonakalo obangelwe yi-alloxan, kusikisela ukuthi ikhasi lingasebenza ngempumelelo ekulweni nesifo sikashukela sohlobo 1 lapho umzimba ungakwazi ukukhipha i-insulin kahle.
Futhi, okuqukethwe kwe-ascorbic acid, i-polyphenols kanye ne-flavonoids kutholakele kumaxolo ekhukhamba asho ngokusobala ngomphumela olwa nesifo sikashukela wale veggie ebalulekile. [7]
Ukuphetha
Ikhukhamba lingafakwa ngokuphepha ekudleni kwesifo sikashukela ngenxa yokulwa nokuvuvukala, ama-antioxidants kanye nezakhiwo zokulwa nesifo sikashukela. Abantu abanesifo sikashukela bangayifaka esaladini noma ekudleni kwabo. Kodwa-ke, khumbula njalo ukuthi ukudla kunika umphumela ozuzisayo kuphela uma kwenziwa kanye nemisebenzi yomzimba. Yenza ukuvivinya umzimba njalo kanye nezinye izinguquko zendlela yokuphila ukuvimbela ukuqala kwesifo sikashukela.
