Ngabe iPolycystic Ovary Syndrome (PCOS) Iyayandisa Ingozi Yokutheleleka nge-COVID-19?

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Izingozi ezivelayo ze-COVID-19 zibandakanya iminyaka, ubulili, umfutho wegazi ophezulu, isifo sikashukela nokukhuluphala ngokweqile. Muva nje, obunye ubufakazi bomtholampilo nezifundo ziphakamise ukuhlangana okungenzeka phakathi kwe-PCOS ne-COVID-19.

Ucwaningo luthi abesifazane abaphethwe yi-polycystic ovary syndrome (PCOS) noma i-polycystic ovarian disease (i-PCOD) bangaba sengozini enkulu yokutheleleka nge-COVID-19 uma kuqhathaniswa nabesifazane abangenawo ama-PCOS. Lo mbhalo uzodingida ukuthi kanjani futhi kungani kungenzeka lokho. Funda ukuze wazi kabanzi.

I-COVID-19 Nabesifazane Abahlushwa I-PCOS

Ngokuya ngocwaningo olushicilelwe kwi-European Journal Of Endocrinology, abesifazane abane-PCOS basengozini engamaphesenti angama-28 yokutheleleka nge-COVID-19 uma kuqhathaniswa nabesifazane abangenaleso simo. Umphumela wabalwa ngemuva kokulungisa iminyaka, i-BMI kanye nobungozi bengozi. [1]

Ngaphandle kwalokhu okushiwo ngenhla, ukuhlaziywa bekukhombisile ukuthi abesifazane be-PCOS basengozini enkulu ngamaphesenti angama-51 ye-COVID-19 phakathi kwabesifazane ngaphandle kwe-PCOS.

Kungani Iziguli Ze-PCOS Zisengozini Ekhulayo Ye-COVID-19?

Kusukela namhlanje, i-COVID-19 isithinte abantu ababalelwa ezigidini eziyi-124 emhlabeni jikelele, ngamacala atholakele angama-70.1 million nokufa kwabantu abayizigidi ezingama-2.72. Ucwaningo oluningi olushicilelwe lukhombisile ukuthi amacala e-COVID-19 aqinisekiswe elebhu atholakala kakhulu kwabesilisa emazweni amaningana uma kuqhathaniswa nabesifazane.

Yize imbangela iyi-multifactorial, umphumela wehomoni ye-androgen ubhekwa njengesinye sezizathu eziyinhloko zokwehluka okuqondene nocansi kuzinga lokutheleleka.

I-Androgen ibizwa kakhulu nge-hormone yabesilisa elawula ukuthuthukiswa kanye nokugcinwa kwezici zabesilisa nemisebenzi yabo yokuzala. [okubili]

I-hormone, nokho, ikhona kokubili kwabesilisa nabesifazane, kodwa umsebenzi wayo oyinhloko ukuvuselela i-testosterone ne-androstenedione, amabili kwama-hormone wesilisa amaningi ocansi.

I-PCOS yisifo se-endocrine lapho amazinga e-androgens (ama-hormone wesilisa) enyuka, esikhundleni se-estrogen (i-hormone yabesifazane). Lokhu kuholela kwi-hyperandrogenism kanye nokungasebenzi kahle kwe-ovari, kubangele ukungabi nenzalo kwabanye ngaphandle kokuxilongwa nokwelashwa okufanele.

Njengoba i-hormone ye-androgen ithathwa njengesihluthulelo sengozi yokutheleleka nge-COVID-19, kungashiwo ukuthi abesifazane be-PCOS bangavezwa kakhulu ukugula, uma kubhekwa ukuthi ezinye izinto ezinjengokukhuluphala kwabesifazane be-PCOS nazo zingaba imbangela.

Ezinye Izinto

1. Ukumelana ne-insulin

I-PCOS ixhunyaniswe nokuphazamiseka kwemetabolism njengokumelana ne-insulin nesifo sikashukela. I-insulin yi-hormone esiza ukuphatha amazinga e-glucose emzimbeni, kanye nokulawula imetabolism yamaprotheni nama-lipids.

Ukumelana ne-insulin kuyakhiwa lapho umzimba ungaphenduli ku-insulin, kubangele ukungasebenzisi i-glucose egazini ukuthola amandla, okuholela ekwandeni kwe-glucose yegazi. Ukweqisa kwe-glucose kuqala ukuphazamisa amangqamuzana omzimba afana nama-B cell, ama-macrophage nama-T cell, okuholela ekwehleni kwemisebenzi yokuzivikela.

Ukungasebenzi kwamasosha omzimba ngenxa yokumelana ne-insulin, okwaqala ngenxa ye-PCOS ekugcineni kungasho ukuthi kungani abesifazane abane-PCOS bethinteka kakhulu nge-coronavirus. [3]

2. Ukukhuluphala ngokweqile

Ucwaningo lukhombisile ukuthi ngemuva nje kokuvela kwe-coronavirus, phakathi kwabantu ababenomoya, isilinganiso seziguli ezikhuluphele sasiphezulu, kwalandela ukwanda kwezinga lokufa phakathi kwalaba bantu. [4]

Olunye ucwaningo luye lwaqhakambisa nokuthi ngesikhathi sobhadane lwangaphambilini lokutheleleka nge-H1N1 noma i-swine flu, ubunzima besimo bebuphezulu kubantu abakhuluphele. [5]

Cishe amaphesenti angama-38-88 abesifazane abane-PCOS batholakala ukuthi bakhuluphele ngokweqile noma bakhuluphele. Ukuxhumana okuseduze phakathi kokukhuluphala, i-PCOS ne-COVID-19 kungaphetha, ukuthi abesifazane be-PCOS bathinteka kakhulu ku-COVID-19 ngenxa yokukhuluphala ngokweqile noma ukukhuluphala.

3. Ukushoda kukavithamini D

Ukushoda kuka-Vitamin D kuxhumene nokutheleleka kwe-PCOS ne-COVID-19 ngezindlela eziningi. I-Vitamin D iyi-vithamini ebalulekile engasiza ekuvimbeleni izifo zokuphefumula ze-COVID-19 ngempahla yayo ekhulisa amasosha omzimba futhi inciphise ama-cytokines okuvuvukala aholela ku-pneumonia.

Cishe ngamaphesenti angama-67-85 abesifazane abane-PCOS, kuye kwatholakala ukuntuleka okuphezulu kwe-vitamin D. [6]

Ukuntuleka kukavithamini D kungadala ukungasebenzi komzimba, ukwanda kwama-cytokines okuvuvukala kanye nengozi eyengeziwe yezinkinga ezifana nesifo sikashukela, ukumelana ne-insulin nokukhuluphala, zonke izinkinga ze-PCOS.

Ngakho-ke, kungashiwo ukuthi ukushoda kukavithamini D kungaxhunyaniswa ne-PCOS nokwanda kwezinkinga nezinga lokufa ngenxa ye-COVID-19.

4. I-microbiota enhle

I-gut dysbiosis noma ukungasebenzi kahle kwe-gut microbiota kuhlotshaniswa nezimo zezempilo ezifana ne-PCOS.

I-PCOS nempilo yamathumbu iyahambisana. Abesifazane abane-PCOS bavame ukutholakala nge-gut dysbiosis. Kodwa-ke, uma amazinga kashukela ephethwe kahle futhi uhlelo lokugaya ukudla lunakekelwa ku-PCOS, impilo yamathumbu ingathuthukiswa.

Ukuguqulwa ekwakhiweni kwe-gut microbiome kungathinta amasosha omzimba, uhlelo oluyinhloko lomzimba olusivikela ezifweni ngakho-ke, lusenze sithambekele ezifweni ezinjenge-COVID-19.

Ukusetshenziswa kwama-probiotic ukugcina ibhalansi ye-microbiota yamathumbu kungasiza ukukhulisa amasosha omzimba nokuvikela ubungozi be-COVID-19.

Ukuphetha

Ukumelana ne-insulin kungakhuphula ukukhiqizwa kwama-androgens kwabesifazane abane-PCOS. Ukukhuluphala nokukhuluphala ngokweqile kungakhathaza ukumelana ne-insulin futhi ngalokho, kuthuthukise ukukhiqizwa kwe-androgen. Lokhu kungadala ukungasebenzi kahle kwamasosha omzimba ngenxa ye-endocrine-immune axis, engahle inyuse ubungozi be-COVID-19 kwabesifazane be-PCOS.

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